The National Institutes of Health (NIH) is forecasting a funding opportunity announcement for Cancer Center Support Grants (CCSGs) to support NCI-Designated Cancer Centers. The purpose of these grants is to capitalize on all institutional cancer research capabilities, integrating meritorious research into a single transdisciplinary research enterprise across all institutional boundaries. The grants will support three types of Cancer Centers: Comprehensive Cancer Centers, Clinical Cancer Centers, and Basic Cancer Centers. The Cancer Centers are expected to serve as major sources of discovery of the nature of cancer and of development of more effective approaches to prevention, diagnosis, and therapy. • The grants will support research in basic laboratory, clinical, and prevention, control, and population-based research. • The Cancer Centers are expected to contribute significantly to the development of Shared Resources that support research. • The Cancer Centers are expected to collaborate and coordinate their research efforts with other NCI-funded programs and investigators. • The Cancer Centers are expected to disseminate research findings for the benefit of the community.