This initiative will support multi-level and/or multi-domain intervention research to reduce disparities in liver diseases and liver cancer among populations who experience health disparities in the United States. The research should focus on addressing disparities in liver diseases and liver cancer, and should be based on the principles of health equity and social determinants of health. Some possible areas of focus include: • Developing and testing interventions to reduce disparities in liver disease screening and diagnosis • Examining the impact of social determinants of health on liver disease disparities • Investigating the role of healthcare access and quality in perpetuating liver disease disparities • Developing and testing interventions to improve liver disease treatment outcomes in disadvantaged populations • Examining the impact of policy and environmental factors on liver disease disparities.