The Mathematical Sciences Infrastructure Program aims to foster the health of the mathematical sciences research community by supporting core research, training projects, and conference/workshop proposals. Proposals should demonstrate engagement in developing or enhancing the mathematical sciences research infrastructure in the U.S. and explain the regional or national scale impact of the activity. Key aspects of the program include: • Novel projects supporting research infrastructure across the mathematical sciences community • Training projects complementing the Workforce Program • Conference, workshop, and travel support requests with cross-disciplinary activities or national impact • Broadening participation activities, professional development training, and involvement of students and early career researchers The program invites proposals from unrestricted entities, with a focus on projects that can be replicated, promote partnerships, or include broadening participation initiatives.