The National Science Foundation (NSF) is seeking proposals for bold new scientific ideas that tackle ambitious fundamental research problems in computing, communications, and information science and engineering. Proposals should address topics that cross the boundaries of two or more CISE core programs, including Algorithmic Foundations, Communications and Information Foundations, Foundations of Emerging Technologies, Software and Hardware Foundations, Computer Systems Research, Networking Technology and Systems, Human-Centered Computing, Information Integration and Informatics, and Robust Intelligence. Teams should consist of two or more investigators with complementary expertise, and proposals should have total budgets from $3,000,000 to $5,000,000 and durations from 3-5 years. • Proposals should address a topic of interest to two or more core programs. • Proposals should be well suited to large-scale integrated collaborative efforts. • Teams should consist of two or more investigators with complementary expertise. • Proposals should have total budgets from $3,000,000 to $5,000,000 and durations from 3-5 years. • The budget cannot exceed $1,000,000 per year.