The National Institute of Nursing Research (NINR) intends to publish a notice of funding opportunity (NOFO) to support research that seeks to develop, adapt, and/or evaluate social determinants of health (SDOH) interventions, or test strategies for the implementation of SDOH interventions already shown to be effective in rural populations. The research must address SDOH in the development, adaptation, implementation, or evaluation of interventions. Some examples of potential research topics include: • Developing and evaluating SDOH interventions to mitigate the impacts of adverse SDOH and/or bolster positive SDOH in rural populations • Adapting evidence-based interventions to specific rural communities and testing for acceptability and efficacy or effectiveness • Conducting pragmatic and implementation studies, including hybrid effectiveness/implementation studies of adapted interventions or intervention bundles • Evaluating the impact of events or policies on rural populations, such as the closing of a local hospital or the opening of a new employment center.