The Department of Defense (DoD) is soliciting applications for the Peer Reviewed Medical Research Program (PRMRP) Technology/Therapeutic Development Award. This award mechanism is intended to support the translation of promising preclinical findings into products for clinical applications, including prevention, detection, diagnosis, treatment, or quality of life, for a disease or condition related to one of the FY25 PRMRP topic areas and one of the FY25 PRMRP strategic goals. The program expects the research proposed will take an already established proof-of-concept or prototype through the final stages of preclinical development, with the goal of regulatory filing or translation of findings into clinical practice. • The PRMRP challenges the scientific and clinical communities to address the congressionally mandated FY25 PRMRP topic areas with original ideas that foster new directions along the entire spectrum of research and patient care. • The program announcement includes a list of topic areas and strategic goals, which can be found in the document. • The maximum period of performance is 4 years, and the maximum award amount is $3.5 million. • The application process involves a two-step process, with a pre-application (Letter of Intent) due on June 9, 2025, and a full application due on July 21, 2025.