The National Institute of Arthritis and Musculoskeletal and Skin Diseases intends to publish a Notice of Funding Opportunity to solicit applications for continuing research on advancing the field of regenerative medicine using adult stem cells. The initiative will take advantage of remaining funds authorized through the 21st Century Cures Act. • The opportunity is for investigator-initiated studies, and applications are not being solicited at this time. • Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects. • Investigators who have been previously funded through the Regenerative Medicine Innovation Project are encouraged to begin to consider applying for this new NOFO. • The estimated funding for this opportunity is $400,000. • The opportunity is for a cooperative agreement, and the funding activity category is health.