The National Institute on Aging (NIA) intends to publish a Notice of Funding Opportunity (NOFO) to solicit new, renewal, and competing revision applications for research project cooperative agreements. The proposed research must be relevant to the mission of NIA, which includes genetic, biological, neuroscientific, preclinical, clinical, behavioral, social, psychological, and economic research on aging and the health and well-being of older people. The NOFO will utilize the U01 activity code, which requires substantial programmatic involvement. • The research areas of focus include aging and the aging process, diseases and conditions associated with aging, and other special problems and needs associated with growing older. • The NIA places major emphasis on research on Alzheimer's disease (AD) and Alzheimer's disease-related dementias (ADRD). • Prospective applicants are strongly encouraged to contact NIA program staff prior to submitting an application to discuss the responsiveness of their proposed research to the NOFO and its relevance to NIA’s programmatic priorities.