The Defense Advanced Research Projects Agency (DARPA) Defense Sciences Office (DSO) is soliciting proposals that investigate innovative approaches that enable revolutionary advances in science, devices, or systems for national security applications. Proposals should address one or more of the following technical thrust areas: Materials, Manufacturing, and Structures; Sensing, Measuring, and Affecting; Math, Computation, and Processing; and Complex, Dynamic, and Intelligent Systems. Proposals will be evaluated based on overall scientific and technical merit, potential contribution and relevance to the DARPA mission, and cost and schedule realism. • The proposal should investigate innovative research approaches that enable revolutionary advances. • The proposal should provide a detailed technical rationale and a clear description of the proposed technical approach. • The proposal should identify major technical risks and planned mitigation efforts. • The proposal should demonstrate a clear understanding of the costs and level of effort needed to successfully accomplish the proposed technical approach.