The National Institute of Neurological Disorders and Stroke (NINDS) intends to publish a Notice of Funding Opportunity (NOFO) to provide longer-term support and increased freedom and flexibility to Program Directors/Principal Investigators. This Research Program Award (RPA) will allow investigators to advance their long-term research goals, explore exciting research opportunities, and mentor students and postdoctorates. The benefits of the RPA include a more stable funding environment, flexible funding, reduced time spent writing grant applications, and more time for mentoring. • A more stable funding environment, facilitating the pursuit of longer-term research goals • Flexible funding, enabling investigators to pursue research opportunities as they arise • Reduced time spent writing grant applications and managing multiple grant awards • More time for PDs/PIs to mentor the biomedical workforce