This opportunity is for research grant applications focused on developing next-generation human cell-derived microphysiological systems (MPS) and related assays that replicate complex nervous system architectures and physiology with improved fidelity over current capabilities. The goal is to enable future studies of complex nervous system development, function, and aging in healthy and disease states. Key aspects of this opportunity include: • Developing next-generation human cell-derived microphysiological systems (MPS) and related assays • Replicating complex nervous system architectures and physiology with improved fidelity • Enabling future studies of complex nervous system development, function, and aging • Focusing on healthy and disease states This opportunity is relevant to applicants with expertise in biomedical research, particularly those with experience in microphysiological systems, nervous system development, and disease modeling.