The National Institutes of Health (NIH) and the Centers for Disease Control (CDC) intend to publish a Notice of Funding Opportunity (NOFO) to invite eligible United States small business concerns to submit Small Business Innovation Research (SBIR) grant applications. The NOFO will utilize the R43/R44 activity code and will encourage collaborative investigations combining expertise. The opportunity is open to United States small businesses that have the research capabilities and technological expertise to contribute to the R&D mission(s) of the NIH and CDC awarding components. • The NOFO will support SBIR Phase I, Phase II, Direct to Phase II, Fast-Track, and Phase IIB grant applications. • The opportunity is contingent upon reauthorization and extension of the SBIR program. • The estimated synopsis posting date is October 1, 2025, and the estimated application response date is January 5, 2026. • The estimated award date is June 1, 2026, and the estimated project start date is July 1, 2026.