The National Institutes of Health (NIH) is soliciting applications for Bioengineering Research Grants (BRG) to encourage collaborations between the life and physical sciences. The purpose of this funding opportunity announcement is to apply a multidisciplinary bioengineering approach to solve biomedical problems and integrate promising tools, methods, and techniques for specific research or clinical problems. Key aspects of this opportunity include: • Encouraging collaborations between life and physical sciences • Applying bioengineering approaches to biomedical problems • Integrating promising tools, methods, and techniques for research or clinical problems • Supporting small teams with an integrative approach to increase understanding and solve problems in biological, clinical, or translational science • Allowing design-directed, developmental, discovery-driven, or hypothesis-driven research