The Defense Advanced Research Projects Agency (DARPA) is hosting a hybrid Industry Day to introduce the science and technology community to the PROtein SEquencing (PROSE) program vision and goals. The program aims to demonstrate molecular readers that can accurately read a broad range of amino acids and post-translational modifications in sequence for unknown protein samples. The Industry Day will include overview presentations, team building opportunities, and meetings with the government team. • The program will seek hardware demonstrations of novel read element designs integrated with microsystem architectures. • The program is open to a wide range of translocation and measurement approaches as well as microsystem designs. • Successful teams would likely be highly interdisciplinary, integrating expertise in several key areas, including protein chemistry and biochemistry, microfabrication and materials science, and advanced data analysis and algorithm development. • The program is anticipated to be a 36-month program with a 15-month Phase 1 and a 21-month Phase 2.