The National Institutes of Health (NIH) is seeking applications for the Centers of Excellence in Genomic Science (CEGS) program, which aims to bring together interdisciplinary teams of investigators to address challenging biomedical questions from a genomics perspective. The program seeks to develop highly innovative novel concepts, methods, approaches, tools, and technologies to address these questions and achieve a transformative advance. Each CEGS is required to have outstanding scientific plans and management strategies that balance a high level of risk with the potential for high payoff. The program also aims to broaden the pool of researchers able to work in or use genomics and to disseminate CEGS-developed methods and tools to the broader research community. Key aspects of the opportunity include: • The program is open to various types of organizations, including nonprofits, private institutions of higher education, and small businesses. • The estimated funding for the program is $5,000,000. • The program is expected to support 2 awards. • The estimated application response date is June 24, 2026. • The estimated award date is April 1, 2027.