The PROactive Solutions for Preserving Resilience (PROSPR) program aims to develop interventions that extend healthspan by 20 years by targeting the underlying causes of age-induced health loss. The program has three technical areas: TA1 focuses on developing a PROSPR intrinsic capacity score and in-home assessment technology, TA2 focuses on repurposing FDA-approved interventions for healthspan extension, and TA3 focuses on identifying second-generation interventions. The program will last for 60 months and will involve multiple phases, including preclinical validation, clinical trials, and commercialization. Some key points about the program include: * The program aims to develop interventions that can extend healthspan by 20 years. * The program has three technical areas, each with its own specific goals and objectives. * The program will involve multiple phases, including preclinical validation, clinical trials, and commercialization. * The program will last for 60 months. * The program will involve collaboration between different teams and with the FDA. * The program will require the development of a PROSPR intrinsic capacity score and in-home assessment technology. * The program will require the identification of biochemical markers and the development of second-generation interventions.