The NIH Director's New Innovator Award Program supports early-stage investigators of exceptional creativity who propose bold and highly innovative research projects with the potential to produce a major impact on broad, important areas relevant to the mission of NIH. The program is part of the High-Risk, High-Reward Research program and will utilize the DP2 (Clinical Trials Optional) activity code. • The program supports research in all topics relevant to the broad mission of NIH, including behavioral, social, biomedical, applied, and formal sciences. • Applicants must be an Early Stage Investigator, as defined by NIH, and only single PD/PI applications are allowed. • The estimated funding for this program is $37,700,000, and the award ceiling is $475,000. • The application response date is August 19, 2025, and the estimated award date is September 21, 2026.