The NSF Directorate for Engineering and the UKRI Engineering and Physical Sciences Research Council are announcing the ENG-EPSRC Lead Agency Opportunity. This opportunity aims to reduce barriers for researchers working internationally by allowing US and UK researchers to submit a single collaborative proposal that will undergo a single review process. Proposals should be in areas at the intersection of CBET, CMMI, and/or ECCS with the EPSRC Engineering, ICT and/or Manufacturing the Future Themes. • The proposal should include at least one US-eligible collaborator as lead PI and at least one UK-eligible collaborator as senior personnel. • Proposers should review the CBET, CMMI, and ECCS Program Descriptions for research supported through these divisions and the EPSRC website for further information on eligible areas of research. • Proposals are expected to adhere to typical proposal budgets and durations for the relevant NSF programs and EPSRC Themes from which funding is sought.