The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) intends to publish a Notice of Funding Opportunity (NOFO) to solicit applications for continuing research on advancing the field of regenerative medicine using adult stem cells. This initiative will utilize the UH3 activity code and will take advantage of remaining funds authorized through the 21st Century Cures Act. Investigators who have been previously funded through the Regenerative Medicine Innovation Project are encouraged to begin to consider applying for this new NOFO. Key aspects of this opportunity include: • The use of adult stem cells for regenerative medicine research • The UH3 activity code for this initiative • The remaining funds authorized through the 21st Century Cures Act • The encouragement for previously funded investigators to apply for this new NOFO • The various eligible applicant types, including independent school districts, private institutions of higher education, state governments, and nonprofits having a 501(c)(3) status with the IRS.