The Maximizing Investigators' Research Award (MIRA) provides support for the program of research in an investigator's laboratory that is within the mission of NIGMS. The goal of MIRA is to increase the efficiency and efficacy of NIGMS funding. This program aims to increase the stability of funding for NIGMS-supported investigators, enhance their ability to take on ambitious scientific projects, and allow for more flexibility in research directions. The award also seeks to reduce the time spent on grant applications and enable investigators to devote more time to mentoring trainees. Key aspects of this opportunity include: • Support for the program of research in an investigator's laboratory within the NIGMS mission • Increased stability of funding for NIGMS-supported investigators • Enhanced flexibility for investigators to follow new research directions • Reduction of time spent on grant applications • Enablement of more time for mentoring trainees • Eligibility for NIGMS-funded investigators and new investigators proposing research within the NIGMS mission • Allowance for renewal applications from current MIRA grantees