The U.S. National Science Foundation (NSF) is soliciting proposals for the Computer and Information Science and Engineering (CISE): Core Programs, Large Projects. This solicitation invites proposals on bold new scientific ideas tackling ambitious fundamental research problems that cross the boundaries of two or more CISE core programs. Proposers are invited to submit proposals with total budgets from $3,000,000 to $5,000,000 and durations from 3-5 years. • The CISE core programs include the Division of Computing and Communication Foundations (CCF), the Division of Computer and Network Systems (CNS), and the Division of Information and Intelligent Systems (IIS). • Proposals should address a topic of interest to two or more core programs and should not be focused on research infrastructure. • Investigators are strongly encouraged to combine their creative talents and complementary expertise to identify compelling and transformative research approaches. • Proposers should submit proposals with a clear description of the research plan, budget, and team members.