The National Institute on Deafness and Other Communication Disorders (NIDCD) intends to reissue a Notice of Funding Opportunity (NOFO) to solicit applications for Clinical Research Center Grants in the mission areas of hearing, balance, smell, taste, voice, speech, or language. The Clinical Research Center provides a vehicle for integrated, multidisciplinary approaches to critical clinical research questions that advance the study of prevention, pathogenesis, pathophysiology, diagnosis, treatment, management or epidemiology of a disease or disorder of hearing, balance, smell, taste, voice, speech, or language. • The P50 provides an avenue for forming a multidisciplinary team that is intended to bring innovative ideas and distinct perspectives to the generation and evaluation of high impact solutions to complex clinical problems. • Responsive applications must include a multidisciplinary team collaborating on a synergistic set of 3-4 research projects addressing a unifying theme. • The research efforts are further supported by an administrative core and 1-2 optional scientific cores to ensure rigorous and efficient progress towards the center’s unifying theme. • Applications may propose a low-risk clinical trial but are not required to (optional).