The Alcohol and Tobacco Tax and Trade Bureau (TTB) is seeking to purchase an Orbitrap mass spectrometer along with a Vanquish Flex ultra-high performance liquid chromatograph. The proposed acquisition is to acquire a UHPLC with an operating pressure rating up to 15,000 psi and compatible with the corresponding MS, and a HRAM-MS equipped with a quadrupole-Orbitrap that has a resolving power of 120,000 at 200 m/z and requires no external gases other than nitrogen. The key requirements for this purchase include: • The UHPLC must have an operating pressure rating up to 15,000 psi and be compatible with the corresponding MS. • The HRAM-MS must be equipped with a quadrupole-Orbitrap that has a resolving power of 120,000 at 200 m/z and requires no external gases other than nitrogen. • The system must be capable of maintaining a mass accuracy of < 1 ppm RMS for at least 5 days. • The system must be compatible with Thermo Fisher Scientific software specific for Orbitrap data files.