The Mind, Machine, and Motor Nexus (M3X) program supports fundamental research that enables intelligent engineered systems and humans to engage in bidirectional interaction in a physics-based environment. The program aims to deepen the understanding of such interactions, particularly in complex and dynamic settings. Proposals submitted to the M3X program must clearly articulate how the proposed work advances knowledge of bidirectional interactions between humans and intelligent engineered systems. Examples include robots assisting in disaster response, smart environments that learn user preferences, and virtual reality-based rehabilitation technologies. Key areas of focus include: • Conceptual Frameworks and Theoretical Modeling • Dynamic Interaction Analysis and Simulation • Innovative Technologies for Enhanced Interaction