The National Institutes of Health (NIH) intends to publish a Notice of Funding Opportunity (NOFO) to solicit applications for research on expanding the scope of an international cardiac surgery research platform. The platform will incorporate various areas of research, including interventional cardiology, peri-operative care, dissemination and implementation science, circadian medicine, and mechanistic science efforts. The goal is to improve the health of adults with cardiovascular disease and associated neurologic complications. Key aspects of the project include: • Expanding the scope of an international cardiac surgery research platform • Incorporating various areas of research, such as interventional cardiology and peri-operative care • Improving the health of adults with cardiovascular disease and associated neurologic complications • Training the next generation of clinical trialists and implementation researchers • Collaborating with broad stakeholders, including academia, small businesses, professional societies, foundations, and international research entities