The National Human Genome Research Institute (NHGRI) intends to publish a Notice of Funding Opportunity (NOFO) to solicit applications to establish an ancient DNA for Modern Genomics (aDMG) program. The goal of aDMG is to establish an ethical resource of ancient and historical human DNA (aDNA) data to advance studies about contemporary human traits and biology. The Data Generation and Resource Center would produce high-quality, whole-genome sequence data from approved aDNA sources and harmonize with existing data to create a centralized data portal. Key aspects of this opportunity include: • Producing high-quality, whole-genome sequence data from approved aDNA sources • Harmonizing with existing data to create a centralized data portal • Establishing an ethical resource of ancient and historical human DNA (aDNA) data • Advancing studies about contemporary human traits and biology • Collaborative investigations combining expertise in DNA sequencing methods and technology, computational genomics and data science, human evolution, and ancient human populations.