The National Institutes of Health (NIH) is offering an Exploratory/Developmental Research Grant Program to support exploratory and developmental research projects in various fields of biomedical, behavioral, or clinical research. The proposed project must be related to the programmatic interests of one or more of the participating NIH Institutes and Centers (ICs) based on their scientific missions. Applicants should note that some ICs only accept applications proposing mechanistic studies that meet NIH's definition of a clinical trial through this funding opportunity announcement. • The grant program requires at least one clinical trial to be proposed. • The proposed project must involve considerable risk but may lead to a breakthrough in a particular area. • The grant program supports the early and conceptual stages of research projects. • Eligible applicants include various institutions, organizations, and governments.