This opportunity provides funding for national and regional resources that support biomedical research. The resources should provide access to state-of-the-art technologies, methods, and expertise to a large number of researchers. The program aims to achieve economies of scale by serving substantial numbers of users more efficiently and economically than activities maintained by individual institutions. • The resource should be available to any qualified investigator without regard to the particular biomedical focus of their research. • The resource should provide user training and support. • The resource should have a robust web presence and outreach activities to make its capabilities and availability known to the biomedical research community. • The program supports established resources and new ones formed through consolidation of multiple existing regional or local facilities.