The purpose of this notice of funding opportunity (NOFO) is to support research on interventions to improve health in Native American populations. This includes etiologic research, research that develops or tests interventions, and research on dissemination and implementation. The goal is to build upon community knowledge and resilience to test science-based, culturally appropriate solutions to reduce morbidity and mortality. Key areas of focus include: • Etiologic research to inform intervention development • Development, adaptation, or testing of health promotion and disease prevention interventions • Culturally informed treatment or recovery interventions • Dissemination and implementation research to overcome barriers to effective interventions The opportunity is open to various types of organizations, including Native American tribal organizations, nonprofits, and institutions of higher education.