The U.S. Department of Energy (DOE) - Office of Science (SC) is soliciting applications for The Genesis Mission: Transforming Science and Energy with AI. The goal of this project is to accelerate scientific discovery and research and development (R&D) workflows using novel artificial intelligence (AI) models and frameworks. Applicants are expected to propose interdisciplinary teams addressing the Genesis Mission National Science and Technology Challenges. The project will focus on topic areas such as advanced manufacturing, biotechnology, critical materials, nuclear fission, nuclear fusion, quantum information science, semiconductors and microelectronics, discovery science, and energy. Key aspects of the project include: * Proposing small teams with partner institutions from at least two of the following categories: (1) DOE/NNSA National Laboratory or a Scientific User Facility, (2) Industry, and (3) Institute of Higher Education (IHE)/Non-profit/Other * Leveraging the extensive scientific and data resources of the DOE/National Nuclear Security Administration (NNSA), the National Laboratories, U.S. industry, and academia * Integrating the resulting AI models and workflows into the American Science Cloud * Providing cost share commitments, if applicable, and demonstrating institutional or third-party commitment to the proposed activity