The purpose of this notice of funding opportunity (NOFO) is to provide salary support for exceptional Research Software Engineers (RSEs) that contribute their skills to the development and dissemination of biomedical, behavioral or health related software, tools, and algorithms as well as to the training of prospective users of these tools. Key aspects of this opportunity include: * The award is an R50 award, which provides up to 3 years of support. * Eligible applicants include various institutions and organizations, such as universities, non-profits, and small businesses. * The opportunity is focused on supporting research software engineers who contribute to the development and dissemination of biomedical software, tools, and algorithms. * The application due date is December 4, 2026. * The opportunity is sponsored by the National Institutes of Health (NIH). * The award ceiling and floor are not specified, but the opportunity is described as providing salary support for research software engineers.