This opportunity is for exploratory clinical trial grants in arthritis and musculoskeletal and skin diseases. The National Institutes of Health (NIH) is seeking applications for this funding opportunity. The grant is required to have a clinical trial. • The opportunity is open to various types of organizations, including small businesses, non-profits, and institutions of higher education. • The application due date is November 2, 2026. • The grant will support research in the area of arthritis, musculoskeletal, and skin diseases. • The funding instrument for this opportunity is a grant. • The opportunity is listed as a discretionary funding opportunity.