BRAIN Initiative: Exploratory Research Opportunities Using Invasive Neural Recording and Stimulating Technologies in the Human Brain (R61 Clinical Trial Not Allowed)

The National Institutes of Health (NIH) is seeking applications for exploratory research projects that utilize invasive neural recording and stimulating technologies in the human brain. The goal of this research is to understand how dynamic activity of single cells and ensembles of neurons in spatially organized networks gives rise to internal states, such as sensations, perceptions, emotions, thoughts, and memories, and to observable motor and social behaviors. The research should be proposed as exploratory research and planning activities to establish feasibility and early-stage development, with the potential for subsequent research project grant applications. Key aspects of this opportunity include: • The use of invasive neural recording and stimulating technologies in the human brain • The goal of understanding the neural basis of internal states and behaviors • The requirement for exploratory research and planning activities • The potential for subsequent research project grant applications • The need for a Data Management and Sharing Plan • The requirement for annual progress reports and a final report