Illuminating AD/ADRD Genome to Enable Precision Genomic Medicine

The National Institute on Aging (NIA) intends to publish a Notice of Funding Opportunity (NOFO) to solicit applications for a program that supports integrative, cross-disciplinary projects aimed at scaling up mechanistic studies to understand the genomic underpinnings of the pathogenesis and progression of Alzheimer's disease and Alzheimer's disease-related dementias (AD/ADRD). The proposed research projects will employ interdisciplinary approaches that integrate innovative techniques to dissect the genomic drivers of AD/ADRD. Some key aspects of this opportunity include: • The use of advanced analytical methods, including machine learning and comparative genomic analysis across multiple genetic ancestries or multiple neurodegenerative diseases. • The use of cutting-edge tools like genome editing, functional characterization assays, and emerging single-cell and spatial omics technologies. • The use of sophisticated disease models, such as human stem cell-based systems, ex vivo, and in vivo models that reflect different genetic ancestries, various model organisms, or multiple neurodegenerative conditions. • The potential for this initiative to lead to the identification of actionable therapeutic targets for AD/ADRD, meeting the urgent need for mechanism-driven insights that can guide precision medicine approaches for its treatment.