NHLBI Early Phase Clinical Trials for Therapeutics and/or Diagnostics for HLBS Disorders (R61/R33 Clinical Trial Required)

The objective of this funding opportunity is to support investigator-initiated, Phase I clinical trials for diagnostic and therapeutic interventions for heart, lung, blood, and sleep (HLBS) disorders in adults and children. Key aspects of this opportunity include: • Support for final stage preclinical activities needed for the implementation of the proposed trial • A bi-phasic, milestone-driven mechanism of award • The proposed trial can be single or multisite This opportunity is relevant for organizations and individuals interested in conducting early phase clinical trials for therapeutics and/or diagnostics related to HLBS disorders.