NIH Director's Transformative Research Award (R01 Clinical Trial Optional)

The NIH Director’s Transformative Research Award (R01) supports individual investigators or teams that propose bold, high‑risk, high‑reward research with the potential to create new scientific paradigms, clinical approaches, or transformative technologies. Up to six awards will be made, each funded through the NIH Common Fund’s High‑Risk, High‑Reward program. The award is open to a wide range of eligible entities, including U.S. government agencies, non‑profits, higher‑education institutions, tribal governments, and foreign entities. Applications are expected to be submitted by September 3 2027, with awards anticipated in August 2028 and project start in September 2028. No cost‑sharing is required. • Open to diverse applicant types (state, local, tribal, nonprofit, for‑profit, foreign). • Supports high‑impact, unconventional research; clinical trial component optional. • Forecasted award ceiling not specified; typical Transformative awards range up to several million dollars over multiple years. • Submission deadline: September 3 2027; award decision: August 30 2028. • Contact via email only ([email protected]).