Precision and Systems Biology to Uncover the Link Between Chronic and Infectious Diseases

The National Institute of Allergy and Infectious Diseases (NIAID) is seeking to support multidisciplinary, consortium-based research using precision systems biology approaches to uncover links among chronic illnesses, infectious diseases, and microbiomes. The goal is to harness cutting-edge technologies, such as multi-omics, computational modeling, and artificial intelligence, to generate meaningful insights into disease progression and host-pathogen interactions. The research should focus on understanding the pathways by which infections lead to chronic lifelong health issues or how long-term illnesses might predispose or exacerbate acute infections. • The research should use longitudinal patient cohorts and biobank data for comprehensive analysis of genetic, environmental, and lifestyle factors. • The research should aim to advance prevention and treatment strategies for both chronic and infectious diseases. • The research should utilize cutting-edge technologies, such as organoid-based validation systems and integration of real-world data. • The research should improve access to digital health records and advanced clinical informatics tools.