Impact of Immunotherapies on CNS Outcomes in People with HIV: Potential Benefits, Challenges and Risks

The National Institute of Mental Health (NIMH) intends to publish a notice of funding opportunity (NOFO) to solicit biphasic research applications. The primary goal is to generate evidence that informs whether HIV immunotherapies can safely and effectively target CNS HIV persistence while minimizing neurotoxicity and neuroinflammation. • The NOFO will support the development of strategies that contribute to sustained virologic remission across anatomical compartments and improve long-term neurologic and cognitive outcomes in people with HIV. • Investigators with expertise and insights into the impact of HIV immunotherapies on the CNS and viral reservoirs are strongly encouraged to apply to this new NOFO. • The NOFO will utilize the R21/R33 activity code. • The estimated funding for this opportunity is $2,000,000, and the estimated number of awards is 4.