Developing novel theory and methods for understanding the genetic architecture of complex human traits (R21 Clinical Trial Not Allowed)

The goal of this Notice of Funding Opportunity (NOFO) is to support R21 applications for novel theory and methods development that better delineate how genetic and non-genetic factors contribute to complex trait variation across individuals, families, and populations. Approaches should be interdisciplinary across the natural and social sciences, account for interdependencies across scales of biological, social, and ecological organization, and make extensive use of theory, simulations, and validation using available large-scale datasets. The key aspects of this opportunity include: • Interdisciplinary approaches across natural and social sciences • Accounting for interdependencies across biological, social, and ecological organization • Use of theory, simulations, and validation using large-scale datasets • Focus on complex trait variation across individuals, families, and populations