Pilot and Feasibility Studies in Preparation for Substance Use and HIV Prevention Intervention and Services Research Trials

The National Institute on Drug Abuse is seeking to support pilot and feasibility studies in preparation for efficacy, effectiveness, and/or services research trials. The topics may include developing interventions to prevent substance use, misuse, or progression to disorder, substance use prevention, treatment, or recovery services research, and HIV eradication research. The projects may address information gaps, strengthen stakeholder partnerships, or pilot test interventions. Activities might include intervention development/adaptation, assessing intervention or service model acceptability and feasibility, and development of measures, materials, or methods for the future trial. • The grant authorities that allow this forecast are 42 U.S.C. §§ 241 and 284. • Applicants must engage relevant end-users in study design, execution, and interpretation. • A well-defined theory of change or logic model is expected. • Preliminary data is not required. • The estimated synopsis posting date is July 2, 2026, and the estimated application response date is October 2, 2026.