Precision Approaches in Radiation Synthetic Combinations (PAIRS, RP1 Clinical Trial Optional)

The National Cancer Institute (NCI) is soliciting research projects that investigate actionable synthetic vulnerabilities that can be conditionally paired with tumor responses to radiation therapy. The goal of the Precision Approaches in Radiation Synthetic Combinations (PAIRS) program is to develop radiation-synthetic combination strategies and facilitate their adoption into the precision medicine toolkit toward building new and effective anticancer treatments. Key aspects of this opportunity include: • Investigating actionable synthetic vulnerabilities in cancer therapy • Developing radiation-synthetic combination strategies • Facilitating the adoption of these strategies into precision medicine • Supporting innovative cancer therapy strategies that exploit context-dependent effects of radiation therapy • Emphasizing precision, scientific rigor, and reproducibility in research projects