Single Source for the Continuation of the Epidemiology of Diabetes Interventions and Complications (EDIC) Study Research Center (Collaborative U01 Clinical Trial Not Allowed)

The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) seeks a single qualified organization to operate the EDIC Research Center, continuing long‑term follow‑up of the Epidemiology of Diabetes Interventions and Complications (EDIC) cohort. The award is a cooperative agreement (U01) that will fund hypothesis‑driven research, cohort infrastructure, data collection, and collaborative studies using the EDIC data set, biospecimens, and emerging technologies. • Maintain and expand the EDIC cohort infrastructure (clinical visits, biosample storage, data management). • Conduct hypothesis‑based research on type 1 diabetes complications (microvascular, cardiovascular, liver, sleep, mortality, frailty). • Apply advanced analytics (machine learning, AI) and multi‑omic approaches to identify risk phenotypes. • Evaluate emerging therapies (e.g., SGLT2 inhibitors, GLP‑1 agonists) for renal and cardiovascular outcomes. • Share data and biospecimens through the NIDDK Central Repository; comply with NIH Data Management & Sharing Plan. • Provide annual progress reports (RPPR) and financial statements; adhere to NIH grant policies. The award is limited to one application per eligible institution, with an estimated total funding of $6.3 million.