Brain Repair of Any Injured Neural Structure (BRAINS) - Proposers' Day

The Brain Repair of Any Injured Neural Structure (BRAINS) program is an initiative by the Advanced Research Projects Agency for Health (ARPA-H) to develop technologies for regrowing brain tissue. The program aims to demonstrate the feasibility of reversing damage and disease in any part of the brain. The BRAINS Exploratory Topic will consist of two technical areas: generating precursor tissue for any brain region and optimizing surgical engraftment of precursor tissue into adult brains. The program will consist of two 9-month phases, with a performer down-selection at the end of Phase I. • The program will focus on developing methods for generating region-specific precursor tissue. • The program will also focus on demonstrating proof-of-concept for surgical engraftment in preclinical models. • The BRAINS program is complementary to the FRONT program, which focuses exclusively on neocortical tissue. • The program aims to advance technology for generating precursor tissue products that can restore function to damaged regions of the brain. • The program will collect participant questions and make them available in the Frequently Asked Questions (FAQ) section.