The National Institutes of Health (NIH) is seeking applications for the Precision Medicine with Artificial Intelligence - Integrating Imaging with Multimodal Data (PRIMED-AI) program. The program aims to develop innovative, reliable, and cost-effective AI-based tools that integrate clinical imaging with other health data types to enhance personalized medicine for patients with chronic and other health conditions. The Academic Industrial Partnership (AIP) initiative will focus on data integration and interoperability, followed by a second phase focused on algorithm development and performance testing. • The program will utilize the UG3/UH3 activity code. • Applications are not being solicited at this time, but notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects. • Investigators with expertise and insights into AIP collaborations to develop and test AI-based tools using medical images and multimodal data for clinical diagnosis and treatment are encouraged to begin considering applying for this new NOFO. • Collaborative investigations combining expertise in building and managing academic and industrial partnerships will be encouraged and these investigators should also begin considering applying for this application.