The USAMRDC's mission is to provide solutions to medical problems of importance to the American Service Member at home and abroad, as well as to the general public at large. This BAA is intended to solicit extramural research and development ideas using the authority provided by 10 USC 4001. The BAA is issued under the provisions of the Competition in Contracting Act of 1984, as implemented in FAR 6.102(d)(2) and 35.016 and in Department of Defense Grant and Agreement Regulations (DoDGARs) 22.315. Some key points about this opportunity include: * The BAA is continuously open for a 5-year period, from October 1, 2022 through September 30, 2027. * Submission of a pre-proposal/pre-application is required and must be submitted through the electronic Biomedical Research Application Portal (eBRAP). * Pre-proposals/pre-applications may be submitted at any time throughout the 5-year period. * If the USAMRDC is interested in receiving a full proposal/application, the Principal Investigator will be sent an invitation to submit via eBRAP. * A full proposal/application must be submitted through Grants.gov.