Screening and Functional Validation of Genomic Variants Associated with Human Congenital Anomalies (R01 Clinical Trial Not Allowed)

The National Institutes of Health (NIH) is seeking applications for the Screening and Functional Validation of Genomic Variants Associated with Human Congenital Anomalies (R01 Clinical Trial Not Allowed) initiative. This initiative aims to promote the screening, functional validation, and characterization of congenital anomaly-associated genetic variants identified through public-facing databases and individual efforts using in-silico tools, appropriate animal models, in vitro systems, or multi-pronged approaches. • The purpose of this initiative is to address the gap between identifying sequence variations of potential interest and recognizing which of those variations have functional effects on the phenotype of interest. • Applicants may include public and state-controlled institutions of higher education, state governments, independent school districts, small businesses, Native American tribal governments, city or township governments, public housing authorities, nonprofits, and for-profit organizations. • The expected application count is 100, and the expected application size is 0. • The submission deadline is January 7, 2028.