The National Center for Complementary and Integrative Health (NCCIH) intends to publish a Notice of Funding Opportunity (NOFO) to support multi-site feasibility studies of mind and body interventions on whole person health restoration. The goal of this NOFO is to establish foundational work necessary to inform and enable future large-scale clinical efficacy and effectiveness trials of mind and body interventions on whole person health restoration. Key expectations include demonstrating that the mind and body intervention can be delivered with fidelity across sites, assessing feasibility of participant recruitment and retention, and exploring correlations between changes in mechanistic targets and clinical outcome measurements. • The NOFO will support multi-site feasibility studies of mind and body interventions on whole person health restoration. • The goal is to establish foundational work necessary to inform and enable future large-scale clinical efficacy and effectiveness trials. • Key expectations include demonstrating fidelity of intervention delivery, assessing feasibility of participant recruitment and retention, and exploring correlations between mechanistic targets and clinical outcomes. • Applicants are required to use the Whole Person Health Index and may also use one or more of its individual components as the clinical outcome measure of whole person health restoration. • Multidisciplinary teams with experience in complementary and integrative health, clinical trial design, and mechanistic research are particularly encouraged to consider applying.