Assessing the Feasibility of Incorporating Mechanisms in Multisite Clinical Trials of Mind and Body Interventions on Whole Person Health Restoration

The National Institutes of Health (NIH) is seeking to support multi-site feasibility studies of mind and body interventions on whole person health restoration. The goal of this funding opportunity is to establish foundational work necessary to inform and enable future large-scale clinical efficacy and effectiveness trials of mind and body interventions on whole person health restoration. Key expectations include demonstrating that the mind and body intervention can be delivered with fidelity across sites, demonstrating reproducibility and rigor in engaging targeted mechanisms, assessing feasibility of participant recruitment and retention, and exploring correlations between changes in mechanistic targets and clinical outcome measurements. • The intervention must be delivered across at least two geographically distinct sites. • Applicants are required to use the Whole Person Health Index as the clinical outcome measure. • Additional clinical outcome measures are allowable based on clinical relevance. • Multidisciplinary teams with experience in complementary and integrative health, clinical trial design, and mechanistic research are encouraged to apply.