The National Institutes of Health (NIH) is seeking applications for the Maximizing Investigators' Research Award (MIRA) program, which aims to provide support for individual investigators to conduct research within the scientific mission of the National Institute of General Medical Sciences (NIGMS). The program seeks to increase the efficiency of NIGMS funding by providing investigators with greater funding stability and scientific flexibility, enabling them to take on more ambitious and innovative studies. The MIRA program will also help distribute funding more widely among the nation's highly talented and promising investigators. • The program is open to eligible NIGMS-funded investigators and NIH-defined New Investigators proposing research aligned with NIGMS's mission. • The program will allow renewal applications from all current MIRA grantees, including those previously funded as Early-Stage Investigators (ESIs). • NIGMS intends to reissue a separate NOFO to support ESIs through the MIRA program in the future. • The award is a 5-year grant, with an estimated award date of Dec 01, 2026. • The program has a response date of May 26, 2028.