CCRP Initiative: Promoting a Basic Understanding of Chemical Threats to Skin (R01 Clinical Trial Not Allowed)

The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) and the National Institute of Allergy and Infectious Diseases (NIAID) are soliciting applications to investigate the pathological mechanisms of skin injuries caused by toxic Chemicals of Concern (CoC) identified as public health threats by the United States Government. The goal of this initiative is to support the discovery and early development of broad-spectrum medical countermeasures (MCMs) to advance the nation's medical and public health preparedness for, response to, and recovery from high consequence chemical disasters and emergencies. * The initiative will focus on understanding the commonalities in the fundamental mechanisms of skin injuries caused by vesicants such as sulfur mustard, Lewisite, nitrogen mustard, phosgene oxime, arsenicals, and other toxic chemicals. * Responsive applications will investigate the molecular and cellular pathology of at least two chemicals, belonging to different toxidromes. * The initiative is part of a NIH-wide initiative to develop MCM to treat patients in mass casualty events after acute exposure to toxic chemicals as part of the Chemical Countermeasure Research Program (CCRP). * Applicants are encouraged to consider applying for this new funding opportunity, and team science approaches will be encouraged.