The National Institutes of Health (NIH) is seeking applications for the HEAL Initiative: Studies to Enable Analgesic Discovery. The goal of this initiative is to support the development of safe, effective, and non-addictive therapeutics to treat pain. The scope of this opportunity will focus on the development of assays to support a distinct testing funnel, screening efforts to identify hits, and initial characterization of hits and potential therapeutic agents. Key aspects of this opportunity include: • The development of assays to support a distinct testing funnel • Screening efforts to identify hits • Initial characterization of hits and potential therapeutic agents • The opportunity is part of the NIH HEAL Initiative • The award ceiling is $350,000 • The opportunity is open to various types of organizations, including county governments, nonprofits, and small businesses.